Description

Desipramine-D3 Hydrochloride is a deuterium-labeled internal standard of the tricyclic antidepressant desipramine, essential for precise quantitative analysis in bioanalytical research. This high-purity compound is critical for ensuring accuracy and reliability in pharmacokinetic and metabolism studies using mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units for method development and validation.

Application

• LC-MS/MS Internal Standard: Used as a deuterated internal standard for the accurate quantification of desipramine in biological matrices (plasma, serum, urine) via liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic & Bioequivalence Studies: Enables precise measurement of drug concentration-time profiles to assess absorption, distribution, metabolism, and excretion (ADME).
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of assays to monitor desipramine levels in patient samples for dose optimization.
• Forensic & Clinical Toxicology: Employed in confirmatory testing and method development for the detection of tricyclic antidepressants in forensic and clinical settings.
• Drug Metabolism Research: Facilitates studies on the metabolic pathways and stability of desipramine and related compounds.
• Reference Material for GLP/GCP Compliance: Serves as a certified reference material in studies conducted under Good Laboratory Practice (GLP) and Good Clinical Practice (GCP) guidelines.

Basic Information

Product Name	Desipramine-D3 Hydrochloride
CAS No.	1435934-62-5
Molecular Formula	C18H19D3ClN2 • HCl
Molecular Weight	329.28 g/mol (approx.)
Synonyms	10,11-Dihydro-5-[3-(methylamino-d3)propyl]-5H-dibenz[b,f]azepine Hydrochloride; Desmethylimipramine-d3 Hydrochloride; Norimipramine-d3 Hydrochloride; DMI-d3 HCl; 3-(10,11-Dihydro-5H-dibenz[b,f]azepin-5-yl)-N-methyl-d3-propan-1-amine Hydrochloride; NSC 114900-d3 (Hydrochloride); Pertofrane-d3 (Hydrochloride)
EINECS	Contact for details

Quality Control

Our Desipramine-D3 Hydrochloride is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic purity (deuterium incorporation), and residual solvents. We adhere to standards suitable for research and development use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99.0 atom % D (D3)
Chemical Purity	≥95.0% (by NMR)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.