Description

Protriptyline-D3 Hydrochloride is a deuterium-labeled analog of the tricyclic antidepressant protriptyline, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is critical for ensuring accuracy and reliability in pharmacokinetic studies, drug metabolism research, and forensic toxicology. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring precise and reproducible mass spectrometry data.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the accurate quantification of protriptyline in biological matrices (plasma, serum, urine).
• Pharmacokinetic & Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Forensic & Clinical Toxicology: Used in confirmatory testing and therapeutic drug monitoring (TDM) to ensure reliable results in legal and medical diagnostics.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolites, aiding in the understanding of metabolic pathways.
• Method Development & Validation: Serves as a key component in developing, optimizing, and validating robust analytical methods according to GLP/GCP guidelines.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay verification during the production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Protriptyline-D3 Hydrochloride
CAS No.	1435934-21-6
Molecular Formula	C19H18D3N•HCl
Molecular Weight	302.86 g/mol (approx.)
Synonyms	N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine-10,11,11-d3 Hydrochloride; Protriptyline-d3 HCl; Protriptyline (phenyl-d3) Hydrochloride; 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-d3 Hydrochloride; Vivactil-d3 Hydrochloride; Triptil-d3 HCl; MK-240-d3 Hydrochloride; Deuterated Protriptyline Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Protriptyline-D3 Hydrochloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting critical parameters including isotopic purity, chemical purity, and residual solvents. Our quality commitment ensures compliance with the standards required for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (NMR/MS)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.