Description

2-Methyl-5-Trifluoromethoxy-Dl-Phenylalanine, 97% is a non-natural, fluorinated amino acid derivative of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral building block and intermediate in the development of novel pharmaceuticals and agrochemicals, where the trifluoromethoxy group imparts unique metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for constructing complex molecules, particularly in medicinal chemistry programs targeting new active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the effects of fluorine and trifluoromethoxy substitution on drug potency, selectivity, and pharmacokinetic properties.
• Peptidomimetics & Bioactive Peptides: Incorporated into peptide backbones to create analogs with enhanced stability against enzymatic degradation and improved membrane permeability.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand & Catalyst Development: Utilized in the synthesis of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Acts as a precursor for labeling reagents and molecular probes used to study biological processes and protein functions.

Basic Information

Product Name	2-Methyl-5-Trifluoromethoxy-Dl-Phenylalanine, 97%
CAS No.	1435806-20-4
Molecular Formula	C11H12F3NO3
Molecular Weight	263.21 g/mol
Synonyms	DL-2-Methyl-5-(trifluoromethoxy)phenylalanine; (±)-2-Amino-3-[2-methyl-5-(trifluoromethoxy)phenyl]propanoic acid; 2-Methyl-5-trifluoromethoxy-DL-phenylalanine; α-Methyl-5-(trifluoromethoxy)phenylalanine; 5-(Trifluoromethoxy)-2-methyl-DL-phenylalanine; NSC 876193; 2-Methyl-5-(trifluoromethoxy)phenylalanine, DL-
EINECS	Contact for details

Quality Control

Our 2-Methyl-5-Trifluoromethoxy-Dl-Phenylalanine, 97% is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and compliance with customer specifications. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing purity, identity, and impurity profiles. While this material is typically supplied as a research-grade chemical, production can be aligned with cGMP guidelines for advanced development phases upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.