Description

1,1-Difluoro-3-(Iodomethyl)Cyclobutane is a high-value, multi-functional fluorinated building block with a reactive iodomethyl handle. This compound matters for its unique structure, which combines the metabolic stability conferred by the difluorocyclobutane moiety with the versatility of an alkyl iodide for further functionalization. It is primarily needed by research and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases and CNS disorders.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with unique surface properties.
• Fluorination Chemistry: Acts as a versatile scaffold for introducing the cyclobutyl-difluoro motif into complex molecules via cross-coupling reactions (e.g., Suzuki, Negishi).
• Labeled Compound Synthesis: The iodine atom allows for easy radiolabeling (e.g., with I-125) for use in tracer studies and diagnostic imaging agent development.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for catalysis or as a precursor for organometallic reagents.

Basic Information

Product Name	1,1-Difluoro-3-(Iodomethyl)Cyclobutane
CAS No.	1434142-22-9
Molecular Formula	C5H7F2I
Molecular Weight	244.01 g/mol
Synonyms	3-(Iodomethyl)-1,1-difluorocyclobutane; 1,1-Difluoro-3-iodomethylcyclobutane; Cyclobutane, 1,1-difluoro-3-(iodomethyl)-; 1,1-Difluorocyclobutane-3-methylene iodide; (Iodomethyl)difluorocyclobutane
EINECS	Contact for details

Quality Control

Our 1,1-Difluoro-3-(Iodomethyl)Cyclobutane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.