Description

4,5-Difluoro-2-Hydroxyphenylboronic Acid is a high-purity boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, where the boronic acid group enables Suzuki-Miyaura cross-coupling reactions and the phenolic hydroxyl group provides a handle for further derivatization. This compound is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those containing difluorophenol motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in constructing active ingredients for crop protection products, where the fluorine atoms enhance lipophilicity and biological activity.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, resins, and advanced organic frameworks (MOFs/COFs).
• Ligand Synthesis: Utilized for preparing novel bidentate ligands in catalysis for asymmetric synthesis and transition metal complexes.
• Chemical Biology Probes: Acts as a building block for creating fluorescent tags, sensors, and other molecular probes used in diagnostic and research applications.
• Organic Electronic Materials: Incorporated into the backbone of molecules for organic light-emitting diodes (OLEDs) and semiconductors.

Basic Information

Product Name	4,5-Difluoro-2-Hydroxyphenylboronic Acid
CAS No.	1432610-22-4
Molecular Formula	C6H5BF2O3
Molecular Weight	173.91 g/mol
Synonyms	(4,5-Difluoro-2-hydroxyphenyl)boronic acid; 2-Hydroxy-4,5-difluorophenylboronic acid; 4,5-Difluoro-2-hydroxybenzeneboronic acid; Boronic acid, B-(4,5-difluoro-2-hydroxyphenyl)-; 4,5-Difluoro-2-hydroxy phenyl boronic acid; 1432610-22-4; 4,5-DF-2-HPBA
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Hydroxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request. We are committed to meeting the stringent standards required for pharmaceutical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.