Description

Trifluoperazine-D3 Dihydrochloride is a deuterated internal standard of the antipsychotic agent trifluoperazine, specifically designed for high-precision analytical applications. This compound is essential for ensuring accurate quantification and method validation in complex biological matrices, providing superior reliability for research and quality control. It is primarily used by analytical laboratories, pharmaceutical R&D departments, and contract research organizations (CROs) engaged in pharmacokinetic studies, drug metabolism research, and forensic toxicology.

Application

• Quantitative Internal Standard for LC-MS/MS: Critical for the accurate measurement of trifluoperazine in bioanalytical assays, correcting for matrix effects and instrument variability.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used as a reference standard in the confirmation and quantification of trifluoperazine in human plasma, serum, or urine samples.
• Pharmaceutical Quality Control: Serves as a certified reference material for the assay and impurity profiling of trifluoperazine active pharmaceutical ingredients (APIs) and finished dosage forms.
• Method Development and Validation: Provides a stable isotopic label for developing robust, sensitive, and selective analytical methods compliant with FDA and ICH guidelines.

Basic Information

Product Name	Trifluoperazine-D3 Dihydrochloride
CAS No.	1432064-02-2
Molecular Formula	C21H21D3F3N3S • 2HCl
Molecular Weight	480.88 g/mol (for free base C21H21D3F3N3S)
Synonyms	Trifluoperazine-d3 dihydrochloride; 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine-d3 dihydrochloride; Trifluoperazine (phenyl-d3) dihydrochloride; Stelazine-d3 dihydrochloride; Trifluoperazine Internal Standard; Deuterated Trifluoperazine Dihydrochloride; Trifluoperazine D3 Salt
EINECS	Contact for details

Quality Control

Our Trifluoperazine-D3 Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry for isotopic purity and HPLC for chemical purity, to ensure it meets the exacting standards required for use as a certified reference material. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and impurities are provided and traceable to primary standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 99.0 atom % D
Chemical Purity (by difference)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.