Description

Gabapentin-D6 Hcl is a deuterated analog of the pharmaceutical compound Gabapentin hydrochloride, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics industries who require precise measurement of Gabapentin levels.

Application

• Analytical Reference Standard: Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of Gabapentin.
• Pharmaceutical R&D: Enables accurate drug metabolism and pharmacokinetics (DMPK) studies, including bioavailability and bioequivalence testing.
• Clinical Toxicology: Used in forensic and clinical labs for the precise measurement of Gabapentin concentrations in biological matrices (e.g., plasma, serum, urine).
• Method Development & Validation: Serves as a critical component in developing, validating, and transferring robust analytical methods according to ICH and FDA guidelines.
• Quality Control (QC) Testing: Employed in pharmaceutical manufacturing QC to assay active pharmaceutical ingredient (API) purity and batch consistency.
• Stable Isotope Labeling Studies: Facilitates research into the metabolic pathways and degradation products of Gabapentin.

Basic Information

Product Name	Gabapentin-D6 Hcl
CAS No.	1432061-73-8
Molecular Formula	C9H11D6ClNO2
Molecular Weight	215.73 g/mol
Synonyms	1-(Aminomethyl)cyclohexaneacetic-2,2,3,3,5,5-d6 acid hydrochloride; Gabapentin hydrochloride-d6; Gabapentin-D6 hydrochloride; [2,2,3,3,5,5-2H6]-Gabapentin HCl; (1-(Aminomethyl)cyclohexyl)acetic-2,2,3,3,5,5-d6 acid hydrochloride; Gabapentin (hexadeuterated) HCl; Gabapentin Internal Standard (D6); Aclonium-D6 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Gabapentin-D6 Hcl is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity, chemical purity, and stability. Our quality commitment includes comprehensive characterization by NMR, MS, and HPLC to confirm identity, isotopic enrichment, and impurity profile. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting assay, purity, and specific tests relevant to its use as an analytical standard.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0% (by HPLC, area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.