Description

Nadolol D9 is a deuterium-labeled analog of the non-selective β-adrenergic blocker nadolol, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and regulatory testing facilities for pharmacokinetic studies, bioanalytical method development, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical reference compound for the precise quantification of nadolol in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Drug Metabolism and Metabolite Identification: Used in mass spectrometry to differentiate drug-derived metabolites from endogenous compounds, aiding in metabolic pathway elucidation.
• Bioanalytical Method Development and Validation: A key component in establishing robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and stability testing of nadolol-based drug products.
• Forensic and Doping Control Analysis: Assists in the accurate detection and quantification of β-blockers in forensic toxicology and anti-doping programs.

Basic Information

Product Name	Nadolol D9
CAS No.	1432056-38-6
Molecular Formula	C17H20D9NO4
Molecular Weight	312.45 g/mol (approx.)
Synonyms	5-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-2,3-naphthalenediol-d9; (2R,3S)-5-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-cis-2,3-naphthalenediol-d9; Nadolol-d9; Deuterated Nadolol; [2H9]-Nadolol; SQ 11725-d9; Corgard-d9
EINECS	Contact for details

Quality Control

Our Nadolol D9 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically ≥98% D), chemical purity (≥95% by HPLC), and confirming structural identity. Our quality system supports compliance with relevant standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive). Store under an inert atmosphere in a cool, dry place. Keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.