Description

4-Chloro-3,5-Difluorobenzamide is a high-purity, multi-functional aromatic building block of significant commercial and research interest. This compound is valued for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs). It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the stability of the difluorobenzene core.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials due to its aromatic structure and halogen substituents, which influence electronic properties.
• Polymer Modification: Acts as a monomer or cross-linking agent in the production of high-performance polymers with enhanced thermal and chemical resistance.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for introducing the benzamide moiety into complex molecules.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry and material science research, enabling structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-Chloro-3,5-Difluorobenzamide
CAS No.	1431329-78-0
Molecular Formula	C7H4ClF2NO
Molecular Weight	191.56 g/mol
Synonyms	3,5-Difluoro-4-chlorobenzamide; 4-Chloro-3,5-difluorobenzoic acid amide; Benzamide, 4-chloro-3,5-difluoro-; 4-Chloro-3,5-difluorobenzamide; 1431329-78-0; 4-Chloro-3,5-difluorobenzoamide; 4-Chloro-3,5-difluoro-benzamide
EINECS	Contact for details

Quality Control

Our 4-Chloro-3,5-Difluorobenzamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. The product is hygroscopic (moisture-sensitive); ensure containers are sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.