Description

(+)-1,13-Bis[Di(3,5-Dimethylphenyl)Phosphino]-(5Ar,8Ar,14Ar)-5A,6,7,8,8A,9-Hexahydro-5H-[1]Benzopyrano[3,2-D]Xanthene, 97% (R,R,R)-(+)-Xyl-Skp is a high-purity, chiral phosphine ligand of significant importance in advanced asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity and yield in critical C-C and C-X bond-forming reactions, enabling the synthesis of complex chiral molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance catalysts for process development and scale-up.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for producing chiral intermediates in active pharmaceutical ingredients (APIs).
• Asymmetric Cross-Coupling Reactions: Employed in reactions such as Suzuki-Miyaura and Negishi couplings to construct chiral biaryl and other complex molecular architectures with high stereocontrol.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of single-enantiomer drug candidates and key chiral building blocks for oncology, CNS, and cardiovascular therapies.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators for enhanced efficacy and environmental safety.
• Fine Chemical and Fragrance Manufacturing: Enables the asymmetric synthesis of high-value chiral flavors, fragrances, and specialty chemicals.
• Academic and Industrial R&D: Serves as a critical tool for methodology development and exploring new catalytic transformations in academic laboratories and corporate R&D centers.

Basic Information

Item	Details
Product Name	(+)-1,13-Bis[Di(3,5-Dimethylphenyl)Phosphino]-(5Ar,8Ar,14Ar)-5A,6,7,8,8A,9-Hexahydro-5H-[1]Benzopyrano[3,2-D]Xanthene, 97% (R,R,R)-(+)-Xyl-Skp
CAS No.	1429939-35-4
Molecular Formula	C58H58O2P2
Molecular Weight	849.03 g/mol
Synonyms	(R,R,R)-(+)-Xyl-SKP; (R,R,R)-(+)-Xyl-Skewphos; (5Ar,8Ar,14Ar)-5A,6,7,8,8A,9-Hexahydro-5H-[1]benzopyrano[3,2-d]xanthene-1,13-diylbis[di(3,5-dimethylphenyl)phosphine]; (+)-Xyl-Skewphos; SKP Ligand; Chiral Diphosphine Ligand Xyl-SKP
EINECS	Contact for details

Quality Control

Our (+)-1,13-Bis[Di(3,5-Dimethylphenyl)Phosphino]-(5Ar,8Ar,14Ar)-5A,6,7,8,8A,9-Hexahydro-5H-[1]Benzopyrano[3,2-D]Xanthene, 97% (R,R,R)-(+)-Xyl-Skp is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess, ensuring it meets the high standards required for sensitive catalytic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxygen, long-term storage under an inert atmosphere (argon or nitrogen) is strongly recommended to maintain catalytic activity. Store at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Off-white to light yellow powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation [α]D20	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.