Description

(+)-1,13-Bis[Di(4-Methylphenyl)Phosphino]-(5Ar,8Ar,14Ar)-5A,6,7,8,8A,9-Hexahydro-5H-[1]Benzopyrano[3,2-D]Xanthene CAS NO 1429939-32-1 is a high-purity, chiral phosphine ligand of significant interest in advanced asymmetric catalysis. Its value lies in its ability to impart exceptional enantioselectivity and activity in transition metal-catalyzed reactions, which is critical for the efficient synthesis of single-enantiomer compounds. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance ligands for complex synthetic routes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones to produce chiral intermediates for active pharmaceutical ingredients (APIs).
• Cross-Coupling Reactions: Used in asymmetric Suzuki-Miyaura, Heck, and other C-C bond-forming reactions to construct complex, chiral molecular architectures.
• Pharmaceutical Intermediate Synthesis: Enables the production of enantiomerically pure building blocks for drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and oncology.
• Agrochemical Synthesis: Facilitates the creation of chiral herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Academic & Industrial R&D: Serves as a critical tool for methodology development and exploring new catalytic transformations in university and corporate research laboratories.
• Process Chemistry Optimization: Employed to scale up and optimize catalytic steps for commercial manufacturing, improving yield and reducing waste.

Basic Information

Product Name	(+)-1,13-Bis[Di(4-Methylphenyl)Phosphino]-(5Ar,8Ar,14Ar)-5A,6,7,8,8A,9-Hexahydro-5H-[1]Benzopyrano[3,2-D]Xanthene
CAS No.	1429939-32-1
Molecular Formula	C55H48O2P2
Molecular Weight	802.92 g/mol
Synonyms	(+)-DTBM-SEGPHOS; (5Ar,8Ar,14Ar)-5A,6,7,8,8A,9-Hexahydro-5H-[1]benzopyrano[3,2-d]xanthene-1,13-diylbis[bis(4-methylphenyl)phosphine]; DTBM-SEGPHOS; (R)-DTBM-SEGPHOS; SEGPHOS derivative; Chiral bisphosphine ligand; 3,3',5,5'-Tetra-tert-butyl-1,1'-biphenyl-2,2'-diyl)bis[bis(4-methylphenyl)phosphine] analog
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is manufactured and tested under strict quality management systems. We guarantee high chemical and chiral purity through advanced analytical techniques including HPLC, NMR, and chiral chromatography. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay, enantiomeric excess (ee), and impurity profiles to ensure consistency and reliability for your critical catalytic applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized and moisture-sensitive; allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.