Description

(-)-1,13-Bis[Di(3,5-Dimethylphenyl)Phosphino]-(5As,8As,14As)-5A,6,7,8,8A,9-Hexahydro-5H-[1]Benzopyrano[3,2-D]Xanthene, 97% (S,S,S)-(-)-Xyl-Skp is a high-purity, chiral phosphine ligand essential for advanced asymmetric catalysis. This compound is specifically designed to impart high enantioselectivity and catalytic activity in transition metal-catalyzed reactions, enabling the synthesis of complex chiral molecules. It is a critical component for research and development in pharmaceuticals, agrochemicals, and fine chemical manufacturing where precise stereochemical control is paramount.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral intermediates for active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Facilitates cross-coupling and addition reactions with high stereoselectivity for constructing complex molecular architectures.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer drug candidates and chiral building blocks for oncology, CNS, and cardiovascular therapies.
• Agrochemical Research: Used in the development of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research.
• Fine Chemical Production: Applied in the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.

Basic Information

Product Name	(-)-1,13-Bis[Di(3,5-Dimethylphenyl)Phosphino]-(5As,8As,14As)-5A,6,7,8,8A,9-Hexahydro-5H-[1]Benzopyrano[3,2-D]Xanthene, 97% (S,S,S)-(-)-Xyl-Skp
CAS No.	1429939-31-0
Molecular Formula	C55H56O2P2
Molecular Weight	811.00 g/mol
Synonyms	(S,S,S)-(-)-Xyl-Skp; (S,S,S)-(-)-Xyl-Skewphos; (S,S,S)-(-)-Xyl-Skewphos Ligand; (S,S,S)-(-)-1,13-Bis[Di(3,5-Dimethylphenyl)Phosphino]-5A,6,7,8,8A,9-Hexahydro-5H-[1]Benzopyrano[3,2-D]Xanthene; (S,S,S)-(-)-Xyl-H8-Skewphos; (S,S,S)-(-)-Xyl-tetrahydro-Skewphos; (S,S,S)-(-)-Xyl-H8-Skewphos; (S,S,S)-(-)-Xyl-H8-Skewphos Ligand
EINECS	Contact for details

Quality Control

Our (-)-1,13-Bis[Di(3,5-Dimethylphenyl)Phosphino]-(5As,8As,14As)-5A,6,7,8,8A,9-Hexahydro-5H-[1]Benzopyrano[3,2-D]Xanthene, 97% (S,S,S)-(-)-Xyl-Skp is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high performance in sensitive catalytic applications. All products undergo rigorous analytical testing, including HPLC and NMR, to verify identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material should be stored under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). Handle and open containers in a moisture-controlled environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.