Description

3-Benzyloxy-4-Bromobenzotrifluoride is a high-value, multi-functional aromatic building block characterized by its benzyl-protected phenol, bromine, and trifluoromethyl substituents. This unique combination of functional groups makes it an essential intermediate for constructing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and advanced material scientists for applications in cross-coupling reactions, medicinal chemistry, and the synthesis of liquid crystals or organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or intermediate in the production of specialty polymers, liquid crystals for displays, and organic semiconductors.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating compound libraries for high-throughput screening.
• Fluorinated Compound Synthesis: Acts as a source of a benzyloxy-protected, fluorinated aromatic ring system for further functionalization in drug discovery programs.

Basic Information

Product Name	3-Benzyloxy-4-Bromobenzotrifluoride
CAS No.	1429027-74-6
Molecular Formula	C14H10BrF3O
Molecular Weight	331.13 g/mol
Synonyms	4-Bromo-3-(benzyloxy)benzotrifluoride; 1-Benzyloxy-2-bromo-5-(trifluoromethyl)benzene; 3-(Benzyloxy)-4-bromo-α,α,α-trifluorotoluene; 2-Bromo-α,α,α-trifluoro-5-(phenylmethoxy)toluene; 4-Bromo-α,α,α-trifluoro-3-(phenylmethoxy)toluene; Benzene, 1-bromo-2-(phenylmethoxy)-5-(trifluoromethyl)-; 3-Benzyloxy-4-bromo-α,α,α-trifluorotoluene
EINECS	Contact for details

Quality Control

Every batch of 3-Benzyloxy-4-Bromobenzotrifluoride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.