Description

5-Fluoro-2-(Methylthio)Phenylboronic Acid Pinacol Ester is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound is valued for its stability and reactivity, serving as a critical intermediate in the construction of complex molecules via cross-coupling reactions. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging the fluorine and methylthio substituents for enhanced bioactivity.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLED and OFET components, where the boronic ester group enables precise molecular assembly.
• Chemical Biology Probes: Utilized to develop activity-based probes and molecular tags for studying biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	5-Fluoro-2-(Methylthio)Phenylboronic Acid Pinacol Ester
CAS No.	1428532-52-8
Molecular Formula	C₁₃H₁₈BFO₂S
Molecular Weight	268.16 g/mol
Synonyms	5-Fluoro-2-(methylthio)benzeneboronic acid pinacol ester; 2-Fluoro-5-(methylthio)phenylboronic acid pinacol ester; (5-Fluoro-2-(methylthio)phenyl)boronic acid pinacol ester; B-[5-Fluoro-2-(methylthio)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Fluoro-2-methylthiophenylboronic acid pinacol ester; Pinacol 5-Fluoro-2-(methylthio)phenylboronate; CAS 1428532-52-8
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(Methylthio)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC/MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.