Description

Tau Peptide (245-274) (Repeat 1 Domain) CAS NO 1428134-39-7 is a synthetic peptide fragment corresponding to the first microtubule-binding repeat domain of the human tau protein. This high-purity research-grade compound is essential for studying tau protein aggregation, neurofibrillary tangle formation, and the molecular pathology of Alzheimer's disease and other tauopathies. It is a critical reagent for pharmaceutical R&D, academic neuroscience research, and diagnostic assay development, providing a defined molecular tool for investigating disease mechanisms and screening potential therapeutics.

Application

• Neuroscience Research: Fundamental studies on tau protein biochemistry, aggregation kinetics, and filament formation.
• Drug Discovery & Screening: Target compound for high-throughput screening (HTS) assays to identify inhibitors of tau aggregation for Alzheimer's disease therapeutics.
• Antibody Development & Validation: Key antigen for generating and characterizing monoclonal and polyclonal antibodies specific to the tau repeat 1 domain.
• Diagnostic Assay Development: Used as a calibrator or control in ELISA, Western blot, and other immunoassays designed to detect pathological tau species.
• Biophysical Studies: Investigation of peptide structure, conformation, and interaction with microtubules or other binding partners using techniques like NMR, CD spectroscopy, and SPR.
• Toxicity & Mechanism of Action Studies: Evaluation of cellular toxicity and seeding potency in cell-based models of tau pathology.

Basic Information

Item	Details
Product Name	Tau Peptide (245-274) (Repeat 1 Domain)
CAS No.	1428134-39-7
Molecular Formula	C147H238N44O45S
Molecular Weight	~3327.8 g/mol
Synonyms	Tau (245-274) Peptide; Tau Protein Fragment (245-274); Microtubule-Associated Protein Tau Repeat 1 Domain Peptide; Tau R1 Peptide; hTau (245-274); Alzheimer's Disease Tau Peptide; PHF-Tau Peptide (245-274); CAS 1428134-39-7
EINECS	Contact for details

Quality Control

Every batch of Tau Peptide (245-274) (Repeat 1 Domain) is manufactured under controlled conditions and undergoes rigorous analytical characterization to ensure identity, purity, and consistency. Our quality assurance protocol includes HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by AAA)
Solubility	Soluble in water or aqueous buffer
Single Peak on HPLC	Pass
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.