Description

4-Bromo-2-(Trifluoromethoxyphenyl)Acetonitrile is a specialized aromatic nitrile building block featuring both bromo and trifluoromethoxy substituents. This compound is valued for its unique reactivity profile, where the bromine atom serves as a versatile handle for cross-coupling reactions, while the electron-withdrawing trifluoromethoxy group significantly influences the electronic properties of the molecule. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the stability and lipophilicity imparted by the trifluoromethoxy group.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl and heteroaryl structures.
• Fluorine Chemistry: Acts as a valuable scaffold for introducing fluorine-containing motifs into molecules, a common strategy to improve metabolic stability and membrane permeability in drug design.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	4-Bromo-2-(Trifluoromethoxyphenyl)Acetonitrile
CAS No.	1427502-10-0
Molecular Formula	C9H5BrF3NO
Molecular Weight	280.04 g/mol
Synonyms	2-(4-Bromo-2-(trifluoromethoxy)phenyl)acetonitrile; (4-Bromo-2-(trifluoromethoxy)phenyl)acetonitrile; 4-Bromo-2-(trifluoromethoxy)benzyl cyanide; α-Cyano-4-bromo-2-(trifluoromethoxy)toluene; 4-Bromo-α-(trifluoromethoxy)phenylacetonitrile; 2-(4-Bromo-2-(trifluoromethoxyphenyl))acetonitrile; 4-Bromo-2-trifluoromethoxyphenylacetonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Trifluoromethoxyphenyl)Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material is suitable for demanding applications in GMP-intermediate synthesis and advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.