Description

Benzonitrile, 4-Bromo-3-Fluoro-2-Methoxy- CAS NO 1427452-84-3 is a high-purity, multi-substituted aromatic nitrile building block of significant interest in advanced organic synthesis. Its unique halogenated and methoxylated structure makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, leveraging its halogenated aromatic core.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional organic materials.
• Chemical Biology Probes: Useful for synthesizing labeled compounds and molecular probes for biochemical and diagnostic research.
• Custom Synthesis and Scale-Up: A critical building block for contract research and manufacturing organizations (CROs/CMOs) engaged in custom synthesis projects.

Basic Information

Product Name	Benzonitrile, 4-Bromo-3-Fluoro-2-Methoxy-
CAS No.	1427452-84-3
Molecular Formula	C8H5BrFNO
Molecular Weight	230.04 g/mol
Synonyms	4-Bromo-3-fluoro-2-methoxybenzonitrile; 2-Methoxy-4-bromo-3-fluorobenzonitrile; 3-Fluoro-4-bromo-2-methoxybenzonitrile; Benzonitrile, 4-bromo-3-fluoro-2-methoxy-; 1427452-84-3; 4-Bromo-3-fluoro-2-methoxy-benzonitrile; 2-Methoxy-4-bromo-3-fluorobenzocarbonitrile
EINECS	Contact for details

Quality Control

Our Benzonitrile, 4-Bromo-3-Fluoro-2-Methoxy- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material that meets the stringent requirements for pharmaceutical R&D and other high-value applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.