Description

3-Fluoro-3-Methylazetidine Hydrochloride is a high-value, functionalized azetidine building block essential for modern synthetic chemistry. Its unique structure, featuring a fluorine atom and a methyl group on the same carbon of the strained azetidine ring, makes it a critical intermediate for introducing conformational constraint and modulating physicochemical properties in target molecules. This compound is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the research and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the fluorine atom and the azetidine scaffold can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science: Employed in the research of advanced polymers and functional materials, where its rigid, fluorinated structure can impart unique thermal and chemical resistance properties.
• Chemical Biology Probes: Useful for constructing molecular probes and tags to study biological processes and protein-ligand interactions.

Basic Information

Product Name	3-Fluoro-3-Methylazetidine Hydrochloride
CAS No.	1427379-42-7
Molecular Formula	C4H9FN•HCl
Molecular Weight	123.58 g/mol (Free base: 87.12 g/mol)
Synonyms	3-Fluoro-3-methylazetidine HCl; 3-Fluoro-3-methylazetidine hydrochloride; 3-Methyl-3-fluoroazetidine hydrochloride; 1-Azabicyclo[1.1.0]butane, 3-fluoro-3-methyl-, hydrochloride; 3-Fluoro-3-methyl-azetidine HCl salt; Azetidine, 3-fluoro-3-methyl-, hydrochloride; 3-Fluoro-3-methylazetidine monohydrochloride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-3-Methylazetidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.