Description

4-Methylene-1-Boc-D-Proline is a high-value, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block for the construction of complex molecules, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other peptide mimetics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a constrained proline analog, influencing peptide backbone conformation and biological activity.
• Chemical Biology Research: Employed as a tool compound for studying enzyme-substrate interactions and for the synthesis of labeled probes or molecular libraries.
• Asymmetric Synthesis: Acts as a starting material or intermediate in asymmetric catalytic reactions to create enantiomerically pure compounds.
• Prodrug Development: Utilized in the design of prodrugs where the Boc-protected amine and carboxylic acid functionalities allow for targeted release mechanisms.

Basic Information

Product Name	4-Methylene-1-Boc-D-Proline
CAS No.	1427175-11-8
Molecular Formula	C11H17NO4
Molecular Weight	227.26 g/mol
Synonyms	1-Boc-4-Methylene-D-proline; (R)-1-(tert-Butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic Acid; tert-Butyl (2R)-4-methylidene-2-pyrrolidinecarboxylate; D-4-Methylene-1-Boc-proline; Boc-4-Methylene-D-Pro-OH; 4-Methylene-D-proline tert-butyl ester; 4-Methylene-N-Boc-D-proline
EINECS	Contact for details

Quality Control

Our 4-Methylene-1-Boc-D-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.