Description

Dbco-Peg4-Se CAS NO 1427004-19-0 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) and a reactive selenium moiety. This compound is engineered to facilitate efficient, copper-free click chemistry bioconjugation, enabling the stable and site-specific labeling of biomolecules under mild, physiological conditions. It is an essential tool for researchers and developers in biopharmaceuticals, diagnostic assay development, and advanced materials science who require reliable, high-purity linkers for constructing complex molecular architectures.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Enables the stable, site-specific conjugation of cytotoxic agents or imaging probes to monoclonal antibodies via copper-free click chemistry.
• Protein and Peptide Modification: Used for the functionalization of azide-tagged proteins, peptides, and enzymes to introduce selenium-based functionalities or for further derivatization.
• Nanoparticle and Liposome Functionalization: Facilitates the surface engineering of drug delivery carriers for targeted therapy by conjugating targeting ligands or stealth PEG layers.
• Diagnostic Probe Development: Serves as a key component in constructing sensitive detection probes for ELISA, lateral flow assays, and other bioanalytical techniques.
• Hydrogel and Biomaterial Crosslinking: Employed in the development of advanced, biocompatible hydrogels for tissue engineering and controlled drug release applications.
• Small Molecule Prodrug Assembly: Allows for the modular construction of prodrugs by linking active pharmaceutical ingredients (APIs) to targeting or solubilizing moieties.
• Surface Immobilization Chemistry: Used to create functionalized surfaces on biosensors, microarrays, and chips for capturing biomolecules of interest.
• Polymer Chemistry: Acts as a functional monomer or crosslinker in the synthesis of smart polymers with tailored biological properties.

Basic Information

Product Name	Dbco-Peg4-Se
CAS No.	1427004-19-0
Molecular Formula	C33H41N3O8Se
Molecular Weight	694.66 g/mol
Synonyms	DBCO-PEG4-Selenium; DBCO-PEG4-Se; Dibenzocyclooctyne-PEG4-Selenium; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-{2-[2-(2-{2-[(2-selenanylideneethoxy)methoxy]ethoxy}ethoxy)ethoxy]ethoxy})ethylcarbamate; Selenium-PEG4-DBCO; Azadibenzocyclooctyne-PEG4-Selenol; SPAAC Linker, DBCO-PEG4-Se
EINECS	Contact for details

Quality Control

Our Dbco-Peg4-Se is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to maintain stability. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, moderately soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.