Description

3-(2-Fluorophenyl)-5-Methyl-1,2,4-Oxadiazole is a high-value fluorinated heterocyclic building block, a key intermediate in modern organic synthesis. Its core value lies in the strategic incorporation of fluorine and the 1,2,4-oxadiazole ring, which are critical for modulating the physicochemical and biological properties of advanced molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop new active ingredients with improved potency, metabolic stability, and bioavailability.

Application

• Pharmaceutical Intermediate: A crucial scaffold for the synthesis of novel drug candidates, particularly in central nervous system (CNS), oncology, and anti-inflammatory therapeutic areas.
• Agrochemical Research: Serves as a key building block for developing new generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the oxadiazole moiety.
• Material Science Precursor: Used in the research of advanced organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatics enhance stability and performance.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a fluorescent tag or ligand in biochemical assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	3-(2-Fluorophenyl)-5-Methyl-1,2,4-Oxadiazole
CAS No.	1426958-50-0
Molecular Formula	C9H7FN2O
Molecular Weight	178.16 g/mol
Synonyms	5-Methyl-3-(2-fluorophenyl)-1,2,4-oxadiazole; 2-Fluoro-α,α-dimethylbenzenecarbonitrile oxide; 1,2,4-Oxadiazole, 3-(2-fluorophenyl)-5-methyl-; 3-(2-Fluorophenyl)-5-methyl-1,2,4-oxadiazole; (2-Fluorophenyl)-5-methyl-1,2,4-oxadiazole
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Production of 3-(2-Fluorophenyl)-5-Methyl-1,2,4-Oxadiazole is supported by in-process controls and validated analytical methods (HPLC, GC, NMR) to ensure batch-to-batch consistency and high purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. Our quality system is designed to meet the exacting standards of pharmaceutical and agrochemical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.