Description

Thailanstatin A CAS NO 1426953-21-0 is a potent and highly selective natural product compound of significant interest in advanced pharmaceutical research. This molecule matters for its unique mechanism of action, which targets specific cellular pathways involved in disease progression. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel anti-cancer therapeutics and other targeted biological agents.

Application

• Oncology Research: As a lead compound for studying novel mechanisms in cancer cell biology and apoptosis.
• Drug Discovery Programs: Serving as a high-value reference standard or a starting point for medicinal chemistry and structure-activity relationship (SAR) studies.
• Biochemical Pathway Analysis: Used as a selective probe to investigate specific intracellular signaling pathways and protein functions.
• Preclinical Development: Evaluation of pharmacokinetics, pharmacodynamics, and initial efficacy in disease models.
• Academic Research: Fundamental studies in chemical biology to understand natural product biosynthesis and bioactivity.
• High-Throughput Screening (HTS): Utilized as a control or validation compound in screening assays for new therapeutic targets.

Basic Information

Product Name	Thailanstatin A
CAS No.	1426953-21-0
Molecular Formula	C34H48N4O10S
Molecular Weight	704.83 g/mol
Synonyms	Thailanstatin A; TST-A; FR901464 analogue; Splicing inhibitor FR901464; (2S,3S,4R,5R,6R,8R,10S,11S,12S,14R,16S,18S,19S,20R,21S,22S,23S,24S,25S,26R,27S,28S,29S,30S,31S,32S,33S,34S,35S,36S,37S,38S,39S,40S,41S,42S,43S,44S,45S,46S,47S,48S)-45-[(2S,3S,4R,5R,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-44-hydroxy-43-methoxy-42-methyl-41-oxo-40-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-39,46-dioxa-35-azatetracyclo[36.10.1.112,16.02,31]octatetraconta-1(45),2(31),3,5,7,9,11,13,15,17,19,21,23,25,27,29,33,35,37-nonadecaene-34,47-dione
EINECS	Contact for details

Quality Control

Our Thailanstatin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and integrity for critical research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, mass spectrometry (MS) for identity confirmation, and NMR spectroscopy. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Store in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to reference standard
Identification (NMR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.