Description

Naloxone-D5 Hcl CAS NO 1426174-78-8 is a deuterium-labeled internal standard of the opioid antagonist naloxone, essential for precise quantitative analysis in bioanalytical research. This high-purity compound is critical for ensuring accuracy and reliability in mass spectrometry-based assays, where it corrects for matrix effects and instrument variability. It is primarily required by pharmaceutical R&D laboratories, forensic toxicology units, and contract research organizations (CROs) engaged in pharmacokinetic studies, doping control, and clinical diagnostics.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of naloxone and its metabolites in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic & Bioavailability Studies: Enables precise measurement of drug concentration-time profiles in clinical and pre-clinical research.
• Forensic & Clinical Toxicology: Supports confirmatory testing for opioid overdose cases and monitoring of opioid antagonist therapy.
• Doping Control Analysis: Employed in sports anti-doping laboratories for the detection and quantification of prohibited substances.
• Method Development & Validation: Serves as a critical reagent for developing, optimizing, and validating robust analytical methods in compliance with FDA and EMA guidelines.
• Metabolite Identification Studies: Aids in the structural elucidation and quantification of drug metabolites using high-resolution mass spectrometry.

Basic Information

Product Name	Naloxone-D5 Hcl
CAS No.	1426174-78-8
Molecular Formula	C19H16D5ClNO4 • HCl
Molecular Weight	378.85 g/mol (for free base C19H16D5ClNO4)
Synonyms	Naloxone-d5 Hydrochloride; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one-d5 Hydrochloride; (-)-Naloxone-d5 HCl; Naloxone (phenyl-d5) Hydrochloride; N-allylnoroxymorphone-d5 Hydrochloride; 4,5α-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one-d5 HCl; Narcan-d5 (labeled analog)
EINECS	Contact for details

Quality Control

Every batch of Naloxone-D5 Hcl is manufactured and controlled under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing parameters such as chemical purity, isotopic purity, and absence of interfering impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.