Description

Cefadroxil-D4 is a deuterium-labeled analog of the first-generation cephalosporin antibiotic, Cefadroxil, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, such as LC-MS/MS, by correcting for variations in sample preparation and instrument response. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise quantification of Cefadroxil in complex matrices like biological fluids, environmental samples, and pharmaceutical formulations.

Application

• Internal Standard for Bioanalytical Assays: Primary use as a stable isotope-labeled internal standard for the accurate quantification of Cefadroxil in pharmacokinetic, pharmacodynamic, and toxicokinetic studies using LC-MS/MS.
• Pharmaceutical Quality Control & Method Development: Enables precise assay and impurity profiling of Cefadroxil in active pharmaceutical ingredients (APIs) and finished drug products, supporting method validation per ICH guidelines.
• Metabolite Identification & Tracing Studies: Facilitates the identification and quantification of Cefadroxil metabolites in biological systems due to its distinct mass shift, aiding in ADME (Absorption, Distribution, Metabolism, and Excretion) research.
• Environmental & Food Safety Monitoring: Used in analytical methods to detect and quantify trace levels of antibiotic residues in environmental water samples and food products.
• Forensic & Doping Control Analysis: Supports the accurate detection of Cefadroxil in forensic toxicology and anti-doping programs where precise measurement is legally critical.
• Reference Material for Certified Standards: Serves as a high-purity component in the preparation of certified reference materials (CRMs) for laboratory proficiency testing and calibration.

Basic Information

Product Name	Cefadroxil-D4
CAS No.	1426174-38-0
Molecular Formula	C16H13D4N3O5S
Molecular Weight	367.40 g/mol (for D4 labeled form)
Synonyms	(6R,7R)-7-[[(2R)-Amino(2H4)phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cefadroxil (phenyl-D4); Cefadroxil-d4; Cefadroxil (D4); 7-(D4-Phenylglycylamido)-3-methyl-3-cephem-4-carboxylic Acid; Duricef-D4; Ultracef-D4
EINECS	Contact for details

Quality Control

Our Cefadroxil-D4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and structural integrity. Standard testing includes HPLC for chemical purity, NMR and MS for structural confirmation and isotopic purity assessment, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all test results, including assay (by HPLC), isotopic purity (by MS), and identification (by IR & NMR), is provided with every shipment to guarantee traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant in the container. Keep the container tightly sealed when not in use to prevent absorption of moisture from the atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.