Description

Ampicillin-D5 CAS NO 1426173-65-0 is a deuterium-labeled analog of the broad-spectrum β-lactam antibiotic, Ampicillin, specifically designed for use as an internal standard in quantitative mass spectrometry. This stable isotope-labeled compound is essential for ensuring the accuracy and precision of analytical methods in pharmaceutical research and quality control. It is primarily used by analytical chemists and researchers in pharmaceutical development, clinical laboratories, and regulatory testing environments for pharmacokinetic studies, bioanalytical method validation, and drug metabolism research.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of Ampicillin in complex biological matrices such as plasma, serum, and tissue homogenates.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of Ampicillin.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Enables precise measurement of Ampicillin concentrations in patient samples to optimize dosing regimens.
• Veterinary Drug Analysis: Supports residue testing and pharmacokinetic studies of Ampicillin in livestock and companion animals.
• Environmental & Food Safety Testing: Applied in methods for detecting trace-level antibiotic residues in environmental water samples and food products.
• Method Development & Validation: Serves as a key component in developing and validating robust, regulatory-compliant bioanalytical assays (e.g., following FDA/EMA guidelines).

Basic Information

Item	Details
Product Name	Ampicillin-D5
CAS No.	1426173-65-0
Molecular Formula	C16H14D5N3O4S
Molecular Weight	354.41 g/mol (for C16H14D5N3O4S)
Synonyms	(2S,5R,6R)-6-([(2R)-2-Amino-2-phenylacetyl]amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic-2,3,4,5,6-pentadeutero Acid; D5-Ampicillin; Ampicillin (phenyl-d5); Ampicillin-d5; [phenyl-d5]-Ampicillin
EINECS	Contact for details

Quality Control

Every batch of Ampicillin-D5 is manufactured and analyzed under strict quality systems to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Our quality assurance includes comprehensive testing via NMR, HPLC, and mass spectrometry to confirm isotopic enrichment, chemical purity, and identity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.