Description

Cabergoline-D5 is a deuterated internal standard of the dopamine agonist Cabergoline, specifically designed for analytical and research applications. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical researchers, clinical laboratories, and contract research organizations (CROs) requiring precise measurement of Cabergoline in complex biological matrices.

Application

• Quantitative Bioanalysis: Serves as an internal standard for the accurate quantification of Cabergoline in plasma, serum, and other biological fluids using LC-MS/MS and GC-MS methodologies.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolite Identification and Profiling: Aids in the identification and structural elucidation of Cabergoline metabolites by providing a stable isotopic reference point.
• Method Development and Validation: Critical for developing, optimizing, and validating robust analytical methods in compliance with GLP and FDA/EMA guidelines.
• Doping Control and Forensic Analysis: Used in sports anti-doping laboratories and forensic toxicology to confirm the presence and concentration of Cabergoline.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay validation of Cabergoline active pharmaceutical ingredient (API) and finished drug products.

Basic Information

Product Name	Cabergoline-D5
CAS No.	1426173-20-7
Molecular Formula	C₂₆H₃₂D₅N₅O₂
Molecular Weight	~457.62 g/mol
Synonyms	1-[(6-Allylergolin-8β-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethyl-3-(pentadeuteromethyl)urea; Cabergoline-d5; FCE-21336-d5; Dostinex-d5 (labeled analogue); (8β)-N-[3-(Dimethylamino)propyl]-N-[(ethyl-d5)carbamoyl]-6-(2-propen-1-yl)ergoline-8-carboxamide; 6-Allyl-8β-carboxyergoline D5 derivative; Deuterated Cabergoline Internal Standard
EINECS	Contact for details

Quality Control

Our Cabergoline-D5 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms to structure
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.