Description

(4-(2,2,2-Trifluoro-1-Hydroxyethyl)Phenyl)Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and building block featuring a trifluoromethyl-hydroxyethyl moiety protected as a boronic ester. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry and materials science. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of complex, fluorinated target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those incorporating trifluoromethyl groups to enhance metabolic stability and bioavailability.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-tolerant organoboron reagent for palladium-catalyzed carbon-carbon bond formation to create biaryl and heterobiaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the CF3 group is a critical pharmacophore.
• Liquid Crystal & OLED Materials: A precursor for creating fluorinated aromatic cores in advanced electronic and display materials.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for imaging and diagnostic applications.
• Process Chemistry & Scale-up: The pinacol ester protection offers improved stability and handling characteristics for large-scale manufacturing processes.

Basic Information

Product Name	(4-(2,2,2-Trifluoro-1-Hydroxyethyl)Phenyl)Boronic Acid Pinacol Ester
CAS No.	1426082-73-6
Molecular Formula	C15H20BF3O3
Molecular Weight	316.13 g/mol
Synonyms	[4-(2,2,2-Trifluoro-1-hydroxyethyl)phenyl]boronic acid pinacol ester; 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2,2,2-trifluoroethanol; 2,2,2-Trifluoro-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanol; 4-(2,2,2-Trifluoro-1-hydroxyethyl)benzeneboronic acid pinacol ester; Pinacol [4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl]boronate; (4-(2,2,2-Trifluoro-1-hydroxyethyl)phenyl)boronic acid, pinacol ester; CAS 1426082-73-6
EINECS	Contact for details

Quality Control

Our (4-(2,2,2-Trifluoro-1-Hydroxyethyl)Phenyl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical coupling reactions. Certificates of Analysis (COA) with full analytical data are provided to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.