Description

Lithium 1-(Pyridin-2-Yl)-2,6,7-Trioxa-1-Borabicyclo[2.2.2]Octan-1-Uide is a highly specialized organoboron reagent featuring a unique bicyclic structure. This compound is valued for its role as a sterically hindered, air- and moisture-sensitive base and nucleophile in advanced synthetic chemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and fine chemical industries for constructing complex molecular architectures, particularly in metalation and cross-coupling reactions.

Application

• Directed ortho-Metalation (DoM): Acts as a powerful, non-nucleophilic base for the regioselective deprotonation of aromatic substrates, enabling functionalization at specific positions.
• Synthesis of Boronic Acid Derivatives: Serves as a key intermediate or transmetalation agent in the preparation of sensitive boronic esters and acids for Suzuki-Miyaura cross-coupling.
• Pharmaceutical Intermediate Manufacturing: Used in the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex drug candidates requiring precise boron incorporation.
• Advanced Material Research: Employed in the development of novel organic electronic materials, ligands for catalysis, and boron-containing polymers.
• Methodology Development in Organic Synthesis: A valuable tool for academic and industrial researchers exploring new reaction pathways involving boron chemistry.

Basic Information

Product Name	Lithium 1-(Pyridin-2-Yl)-2,6,7-Trioxa-1-Borabicyclo[2.2.2]Octan-1-Uide
CAS No.	1425937-24-1
Molecular Formula	C9H11BLiNO3
Molecular Weight	190.96 g/mol
Synonyms	Lithium 2-Pyridyltriethylborate; Lithium (Pyridin-2-yl)triethylborate; 1-(2-Pyridyl)-2,6,7-trioxa-1-borabicyclo[2.2.2]octan-1-uide, lithium salt; Pyridine-2-yltriethylborolithium; LiPyBEt3; Lithium 2-Pyridyltrihydroborate(1-), Triethyl Deriv.; LTB (Lithium Triethylborate) Pyridine Adduct
EINECS	Contact for details

Quality Control

Every batch of Lithium 1-(Pyridin-2-Yl)-2,6,7-Trioxa-1-Borabicyclo[2.2.2]Octan-1-Uide is manufactured and handled under strict inert atmosphere conditions to ensure integrity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity, identity, and moisture content.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Due to its hygroscopic nature, the container must only be opened in a moisture-free environment, such as a glovebox.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 95.0%
Moisture Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.