Description

n-Butyl L-Z-Isoleucinamide is a specialized chiral building block and protected amino acid derivative. This compound is of significant value in advanced organic synthesis, particularly for the construction of complex peptides and peptidomimetics. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic peptides and small molecule drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce the isoleucine residue with a protected amine functionality.
• Medicinal Chemistry: Serves as a building block for creating libraries of compounds for high-throughput screening and structure-activity relationship (SAR) studies.
• Bioconjugation: Potential use in the modification of biomolecules due to its reactive amide and protected amine groups.
• Chemical Biology Research: Employed in the synthesis of probes and inhibitors to study enzyme function and biological pathways.
• Process Development: Used in scaling up synthetic routes for candidate drugs during preclinical and clinical development phases.

Basic Information

Product Name	n-Butyl L-Z-Isoleucinamide
CAS No.	1423037-56-2
Molecular Formula	C16H24N2O3
Molecular Weight	292.38 g/mol
Synonyms	L-Isoleucine, N2-[(benzyloxy)carbonyl]-, butylamide; Z-L-Ile-NH-Bu; N-Butyl-N'-[(benzyloxy)carbonyl]-L-isoleucinamide; (2S,3S)-2-[[(Benzyloxy)carbonyl]amino]-3-methylpentanoic acid butylamide; Nα-Cbz-L-isoleucine n-butylamide; CBZ-Ile-NH-Bu; N-Carbobenzoxy-L-isoleucine butylamide
EINECS	Contact for details

Quality Control

Our n-Butyl L-Z-Isoleucinamide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS), to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.