Description

Fmoc-Dap(Octanoyl)-Oh is a specialized, protected amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity building blocks to construct complex peptides with specific modifications. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions engaged in the development of novel therapeutic peptides, peptide-based diagnostics, and biochemical tools. Its design allows for the controlled introduction of an octanoyl-modified diaminopropionic acid residue into peptide chains.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the automated synthesis of custom peptides.
• Therapeutic Peptide Development: For the research and production of peptide drug candidates, particularly those requiring lipidation (via the octanoyl group) to enhance membrane permeability or stability.
• Bioconjugation and Probe Synthesis: Used to create peptide-based probes, tags, or conjugates for diagnostic and imaging applications.
• Structure-Activity Relationship (SAR) Studies: Enables the systematic modification of peptide structures to study the impact of specific acylated amino acids on biological activity.
• Biochemical Research: Serves as a reagent in enzymatic studies and for investigating protein-protein interactions.
• Production of Peptide Libraries: For combinatorial chemistry approaches to screen for new bioactive compounds.

Basic Information

Product Name	Fmoc-Dap(Octanoyl)-Oh
CAS No.	1423018-04-5
Molecular Formula	C26H30N2O6
Molecular Weight	466.53 g/mol
Synonyms	Fmoc-Dap(Octanoyl)-OH; N-α-Fmoc-N-β-octanoyl-L-α,β-diaminopropionic acid; Fmoc-L-Dap(Octanoyl)-OH; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(octanoylamino)propanoic acid; Fmoc-Dap(C8)-OH; Nα-Fmoc-Nβ-octanoyl-L-2,3-diaminopropionic acid; Fmoc-3-amino-3-(octanoylamino)propionic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Dap(Octanoyl)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and identity confirmation via mass spectrometry (MS) and infrared spectroscopy (IR). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -15°C. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.