Description

cis-Asenapine is a specific stereoisomer of the atypical antipsychotic compound asenapine, identified by the CAS registry number 1422571-39-8. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis and study of novel neuropsychiatric therapeutics. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the development of advanced central nervous system (CNS) drugs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of asenapine and its structural analogs for antipsychotic medication development.
• Research & Development: Used in preclinical and clinical research to study the structure-activity relationship (SAR) and metabolic pathways of stereoisomeric drug candidates.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development, validation, and impurity profiling of asenapine-based drug substances and products.
• Process Chemistry: Integral to optimizing stereoselective synthesis routes, scaling up production, and ensuring batch-to-batch consistency in active pharmaceutical ingredient (API) manufacturing.
• Academic Studies: Facilitates pharmacological and toxicological research in university and institutional settings focused on neuropharmacology and drug discovery.

Basic Information

Product Name	cis-Asenapine
CAS No.	1422571-39-8
Molecular Formula	C₁₇H₁₆ClNO
Molecular Weight	285.77 g/mol
Synonyms	(3aRS,12bRS)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole; (3aRS,12bRS)-Rel-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole; cis-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole; cis-Asenapine Maleate Intermediate; Asenapine cis-Isomer
EINECS	Contact for details

Quality Control

Our cis-Asenapine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.