Description

S-Acetyl-Peg4-Propargyl is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl group and a protected thiol. This compound is essential for advanced bioconjugation and click chemistry applications, enabling the precise and efficient crosslinking of biomolecules, polymers, and surfaces. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and materials science sectors for drug delivery system development, protein modification, and the creation of functionalized hydrogels and nanoparticles.

Application

• Bioconjugation Reagent: Used for site-specific labeling and crosslinking of peptides, proteins, and antibodies via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• Drug Delivery Systems: Serves as a key building block for constructing PEGylated drug conjugates, enhancing solubility, stability, and pharmacokinetic profiles of active pharmaceutical ingredients (APIs).
• Surface Functionalization: Enables the modification of nanoparticles, quantum dots, and solid supports with bio-active ligands for diagnostic and therapeutic platforms.
• Polymer Chemistry: Acts as a versatile monomer or crosslinker in the synthesis of functionalized hydrogels and smart polymers with tailored properties.
• ADC Development: Facilitates the construction of antibody-drug conjugates (ADCs) by providing a stable, cleavable linker between the antibody and the cytotoxic payload.
• Diagnostic Probe Synthesis: Utilized in the preparation of fluorescent or radioactive probes for imaging and bioanalytical assays.

Basic Information

Product Name	S-Acetyl-Peg4-Propargyl
CAS No.	1422540-88-2
Molecular Formula	C19H34O8S
Molecular Weight	422.54 g/mol
Synonyms	Propargyl-PEG4-S-Acetyl; S-Acetyl-PEG4-propargyl; 1-Propargyl-3,6,9,12-tetraoxapentadecane-15-thiol acetate; Acetyl-PEG4-Propargyl; Propargyl-PEG4-Thioacetate; 15-(Acetylthio)-3,6,9,12-tetraoxapentadec-1-yne; Heterobifunctional PEG linker, Propargyl-PEG4-SAc; 2,5,8,11-Tetraoxatetradec-13-yne-14-thiol acetate
EINECS	Contact for details

Quality Control

Our S-Acetyl-Peg4-Propargyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your research and cGMP-compliant workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and light-sensitive; desiccate upon opening and minimize exposure to air and humidity to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.