Description

4-Formyl-2-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is a high-value, multifunctional boronic ester building block essential for modern synthetic chemistry. This compound is specifically engineered to facilitate efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, enabling the streamlined synthesis of complex, fluorinated aromatic systems. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular construction with trifluoromethyl and formyl functional handles.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those incorporating the metabolically stable trifluoromethyl group.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the unique properties of fluorine enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for creating fluorinated organic electronic materials, including OLEDs, liquid crystals, and polymers with tailored electronic properties.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form biaryl and complex conjugated structures under mild conditions.
• Chemical Library Development: An important reagent for medicinal chemistry and high-throughput screening to create diverse compound libraries for lead discovery.
• Ligand and Catalyst Design: Employed in the synthesis of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	4-Formyl-2-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester
CAS No.	1422268-45-8
Molecular Formula	C₁₄H₁₆BF₃O₃
Molecular Weight	300.09 g/mol
Synonyms	2-Formyl-5-(trifluoromethyl)phenylboronic acid pinacol ester; (4-Formyl-2-(trifluoromethyl)phenyl)boronic acid pinacol ester; 4-Formyl-2-(trifluoromethyl)benzeneboronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzaldehyde; 5-(Trifluoromethyl)-2-formylphenylboronic acid pinacol ester; PINACOL [4-FORMYL-2-(TRIFLUOROMETHYL)PHENYL]BORONATE
EINECS	Contact for details

Quality Control

Our 4-Formyl-2-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and commercial-scale synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.