Description

Benzene, 2-Chloro-1-Iodo-3-(Trifluoromethoxy)- is a highly functionalized aromatic building block of significant interest in advanced organic synthesis. Its unique combination of halogen substituents and a trifluoromethoxy group makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry for introducing halogen and fluorinated motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira, Negishi) due to the presence of both chloro and iodo leaving groups, allowing for sequential functionalization.
• Fluorine Chemistry Research: A valuable reagent for studying the influence of the -OCF3 group on molecular properties and reactivity in organofluorine chemistry.
• Ligand and Catalyst Development: Used to synthesize sophisticated chelating ligands or organocatalysts for asymmetric synthesis.

Basic Information

Product Name	Benzene, 2-Chloro-1-Iodo-3-(Trifluoromethoxy)-
CAS No.	1421620-34-9
Molecular Formula	C7H3ClF3IO
Molecular Weight	321.45 g/mol
Synonyms	1-Chloro-2-iodo-3-(trifluoromethoxy)benzene; 2-Chloro-1-iodo-3-(trifluoromethoxy)benzene; 3-(Trifluoromethoxy)-2-chloro-1-iodobenzene; 1-Iodo-2-chloro-3-(trifluoromethoxy)benzene; 2-Chloro-3-(trifluoromethoxy)iodobenzene; o-Chloro-m-(trifluoromethoxy)iodobenzene
EINECS	Contact for details

Quality Control

Our Benzene, 2-Chloro-1-Iodo-3-(Trifluoromethoxy)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. We employ advanced analytical techniques including GC, HPLC, NMR, and MS for comprehensive characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.