Description

Fmoc-D-β-Homoglutamic Acid(Otbu) CAS NO 1421258-67-4 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical building block for the development of novel peptide-based pharmaceuticals and research tools, offering precise stereochemical control. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on creating complex peptide structures with enhanced stability or specific biological activity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides, particularly in Fmoc-based strategies.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of therapeutic peptides, including hormone analogs and enzyme inhibitors.
• Peptidomimetic Design: Used to incorporate a D-configured β-homoglutamic acid side chain, which can alter peptide conformation, metabolic stability, and receptor binding affinity.
• Bioconjugation and Labeling: The reactive carboxylic acid (protected as OtBu ester) and Fmoc-protected amine allow for selective deprotection and functionalization in bioconjugation chemistry.
• Chemical Biology Research: Employed in the synthesis of custom peptides for studying protein-protein interactions, signal transduction pathways, and as tools for biochemical assays.
• API Development: Acts as a building block in the synthesis of Active Pharmaceutical Ingredients (APIs) for candidate drugs in preclinical and clinical development stages.

Basic Information

Product Name	Fmoc-D-β-Homoglutamic Acid(Otbu)
CAS No.	1421258-67-4
Molecular Formula	C25H29NO7
Molecular Weight	455.50 g/mol
Synonyms	Fmoc-D-β-hGlu(OtBu)-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]pentanedioic acid 5-tert-butyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-β-homoglutamic acid 5-tert-butyl ester; Fmoc-D-β-Homoglutamic acid γ-tert-butyl ester; Fmoc-D-β-hGlu(OtBu); Fmoc-D-β-homo-Glu(OtBu)-OH; D-Fmoc-β-homoglutamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-D-β-Homoglutamic Acid(Otbu) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure stereochemical integrity, meeting the exacting standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.