Description

Olmesartan-D4 is a deuterated analog of the antihypertensive drug Olmesartan, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical research and development laboratories, clinical testing facilities, and contract research organizations (CROs) engaged in drug development and regulatory compliance work.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise measurement of Olmesartan in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of Olmesartan.
• Clinical Research: Enables accurate bioanalysis in clinical trials to determine drug concentration levels in patients, supporting bioavailability and bioequivalence studies.
• Forensic Toxicology: Supports the accurate identification and quantification of Olmesartan in forensic analyses.
• Pharmaceutical Quality Control: Can be utilized in method development and validation for the assay of Olmesartan in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Metabolite Identification: Aids in the structural elucidation of Olmesartan metabolites by providing a stable isotopic reference point.

Basic Information

Product Name	Olmesartan-D4
CAS No.	1420880-41-6
Molecular Formula	C29H26D4N6O6
Molecular Weight	558.62 g/mol
Synonyms	Olmesartan-d4; 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid-d4; Benicar-d4; (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-[[2'-(5-oxo-2H-tetrazol-1-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate-d4; CS-866-d4; RN-112380-d4; RNH-6270-d4
EINECS	Contact for details

Quality Control

Our Olmesartan-D4 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic purity, chemical purity, and residual solvent content. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.