Description

2-Methoxy-3-(trifluoromethyl)pyridine-5-boronic acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, combining a pyridine core with methoxy and trifluoromethyl substituents, makes it an essential reagent for constructing complex molecules with tailored properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and CNS-targeted therapeutic research.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection products, leveraging the trifluoromethyl group's metabolic stability and lipophilicity.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for OLEDs and charge-transporting molecules.
• Chemical Biology Probes: Serves as a versatile handle for bioconjugation and the creation of molecular probes for target identification and validation.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex, high-value compounds for clients.

Basic Information

Product Name	2-Methoxy-3-(Trifluoromethyl)Pyridine-5-Boronic Acid
CAS No.	1420830-61-0
Molecular Formula	C8H7BF3NO3
Molecular Weight	233.95 g/mol
Synonyms	5-Borono-2-methoxy-3-(trifluoromethyl)pyridine; [2-Methoxy-3-(trifluoromethyl)pyridin-5-yl]boronic acid; 2-Methoxy-3-trifluoromethyl-5-pyridineboronic acid; 3-Trifluoromethyl-2-methoxypyridine-5-boronic acid; 5-Pyridineboronic acid, 2-methoxy-3-(trifluoromethyl)-; 2-Methoxy-3-(trifluoromethyl)-5-pyridinylboronic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized to confirm identity, purity, and consistency. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry. Certificates of Analysis (COA) are available upon request. Our quality management system supports the needs of research and development through to pre-clinical and early-phase clinical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.