Description

tert-Butyl 3-(2-Chloroethyl)Pyrrolidine-1-Carboxylate is a protected pyrrolidine derivative featuring a chloroethyl side chain, serving as a versatile and critical building block in advanced organic synthesis. Its primary value lies in its role as a key intermediate for constructing complex nitrogen-containing heterocycles, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity intermediates for lead optimization and scalable synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides that require specific nitrogen heterocycle scaffolds.
• Chemical Biology & Proteomics: Serves as a precursor for designing molecular probes, enzyme inhibitors, and other bioactive tools.
• Ligand & Catalyst Development: Employed in the construction of complex ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up production under cGMP conditions.
• Academic & Industrial R&D: Critical for methodological studies in organic chemistry, including novel ring-forming reactions and functional group transformations.

Basic Information

Product Name	tert-Butyl 3-(2-Chloroethyl)Pyrrolidine-1-Carboxylate
CAS No.	1420811-53-5
Molecular Formula	C11H20ClNO2
Molecular Weight	233.74 g/mol
Synonyms	1-Boc-3-(2-chloroethyl)pyrrolidine; tert-Butyl 3-(2-chloroethyl)-1-pyrrolidinecarboxylate; 1-(tert-Butoxycarbonyl)-3-(2-chloroethyl)pyrrolidine; 3-(2-Chloroethyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine; 1-Boc-3-(2-chloroethyl)azolidine; N-Boc-3-(2-chloroethyl)pyrrolidine; Pyrrolidine, 3-(2-chloroethyl)-, 1-(1,1-dimethylethyl) ester; 1420811-53-5
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(2-Chloroethyl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to relevant standards for pharmaceutical intermediates, and we support audits and regulatory documentation for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.