Description

Dl-Threo-Chloramphenicol-D5 CAS NO 1420043-66-8 is a deuterium-labeled isotopologue of the broad-spectrum antibiotic chloramphenicol, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in complex biological matrices. It is an essential tool for pharmaceutical research, clinical laboratories, and regulatory bodies conducting pharmacokinetic studies, drug metabolism research, and residue testing.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for accurate measurement of chloramphenicol.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of chloramphenicol.
• Clinical & Diagnostic Testing: Enables precise quantification of chloramphenicol in patient serum, plasma, and other biological fluids for therapeutic drug monitoring.
• Veterinary & Food Safety Analysis: Critical for detecting and quantifying chloramphenicol residues in meat, milk, honey, and aquaculture products to ensure compliance with global food safety regulations.
• Forensic & Anti-Doping Analysis: Supports sensitive and confirmatory testing in forensic toxicology and sports anti-doping programs.
• Method Development & Validation: Serves as a key component in developing, validating, and standardizing new analytical methods for chloramphenicol detection.
• Environmental Monitoring: Applied in trace analysis of pharmaceutical pollutants in water and environmental samples.

Basic Information

Product Name	Dl-Threo-Chloramphenicol-D5
CAS No.	1420043-66-8
Molecular Formula	C11H7D5Cl2N2O5
Molecular Weight	326.15 g/mol (deuterated form)
Synonyms	Chloramphenicol-d5; Deuterated Chloramphenicol; Chloramphenicol (phenyl-d5); 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl-d5)propan-2-yl]acetamide; D-threo-Chloramphenicol-d5; L-threo-Chloramphenicol-d5; DL-Chloramphenicol-d5; Internal Standard for Chloramphenicol
EINECS	Contact for details

Quality Control

Our Dl-Threo-Chloramphenicol-D5 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm isotopic enrichment and chemical purity. Certificates of Analysis (COA) are provided, detailing batch-specific data for isotopic purity, chemical purity, and residual solvents, ensuring full traceability and compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant to maintain stability and purity. For long-term storage, consider freezing at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration at Phenyl Ring)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.