Description

Colterol-D9 Acetate is a high-purity, deuterated analog of colterol acetate, specifically designed for advanced research and analytical applications. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on developing and validating analytical methods for β-2 adrenergic agonists.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of colterol and related compounds in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical Metabolism Studies: Used in drug metabolism and pharmacokinetics (DMPK) research to track the absorption, distribution, metabolism, and excretion (ADME) profiles of β-2 agonists.
• Bioanalytical Method Development: Critical for developing and validating robust, sensitive, and specific analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Clinical Research: Supports clinical trial analysis by providing accurate measurement of drug concentrations in patient samples.
• Forensic Toxicology: Can be employed in forensic analysis for the definitive identification and quantification of β-2 adrenergic agents.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the ideal spike for IDMS, the gold-standard technique for achieving high-accuracy quantitative results.

Basic Information

Product Name	Colterol-D9 Acetate
CAS No.	1420043-63-5
Molecular Formula	C13H10D9NO3
Molecular Weight	~247.3 g/mol
Synonyms	1-(3,5-Dihydroxyphenyl)-2-[(1,1-dimethylethyl)amino]ethanol-D9 acetate; (R*,S*)-α-[(tert-Butylamino)methyl]-3,5-dihydroxybenzyl alcohol-D9 acetate; Deuterated Colterol Acetate; Colterol-d9 acetate; 2-(tert-Butylamino)-1-(3,5-dihydroxyphenyl)ethanol-D9 acetate ester
EINECS	Contact for details

Quality Control

Every batch of Colterol-D9 Acetate is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data for identity, purity (HPLC), isotopic enrichment (MS), and residual solvents. Our quality commitment ensures consistency and reliability for your most demanding research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.