Description

Sulfaphenazole-13C6 CAS NO 1420043-53-3 is a stable isotope-labeled analog of the sulfonamide antibiotic Sulfaphenazole, where six carbon atoms are replaced with the Carbon-13 isotope. This compound is essential as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and regulatory testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical trial sample analysis.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Sulfaphenazole and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used to track and measure the parent drug and its metabolic pathways with high specificity, correcting for matrix effects and instrument variability.
• Bioanalytical Method Development & Validation: Serves as a key component in establishing robust, sensitive, and regulatory-compliant (FDA, EMA) analytical methods.
• Clinical and Pre-clinical Research: Enables accurate pharmacokinetic profiling, including parameters like Cmax, Tmax, and AUC, during drug development phases.
• Forensic and Anti-doping Analysis: Provides definitive identification and quantification in specialized testing scenarios requiring the highest level of certainty.
• Quality Control in Reference Material Production: Used in the calibration and verification of certified reference materials (CRMs) for Sulfaphenazole.

Basic Information

Product Name	Sulfaphenazole-13C6
CAS No.	1420043-53-3
Molecular Formula	C1513C6H14N4O2S
Molecular Weight	~287.3 g/mol (exact mass varies with isotopic enrichment)
Synonyms	1-Phenyl-3-(pyridin-2-ylsulfamoyl)pyrazole-13C6; 4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide-13C6; Sulfaphenazole (13C6); [13C6]-Sulfaphenazole; Sulfaphenazole-13C6 Internal Standard; Sulfaphenazole-13C6 Isotopic Label; Sulfaphenazole-13C6 CRM; Stable Isotope-Labeled Sulfaphenazole
EINECS	Contact for details

Quality Control

Every batch of Sulfaphenazole-13C6 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support your regulatory submissions. Certificates of Analysis (COA) are supplied with each shipment, detailing critical parameters such as isotopic purity, chemical purity, and absence of interfering impurities. Our quality commitment aligns with the standards expected for high-value reference materials in GLP/GMP-compliant environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. The product is stable under these conditions when handled appropriately.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Atom % 13C)	≥99% on the labeled positions
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.