Description

(2,2-Difluorocyclobutyl)Methanol CAS NO 1419101-11-3 is a specialized fluorinated building block of significant interest in advanced organic synthesis. Its unique structure, featuring a cyclobutane ring with difluoromethylene and hydroxymethyl groups, makes it a valuable precursor for creating novel molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries. It serves as a key intermediate in the synthesis of complex molecules, particularly for introducing fluorinated motifs that can modulate biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the fluorinated cyclobutane moiety can enhance efficacy and environmental profile.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers, liquid crystals, or advanced materials with tailored thermal and chemical resistance properties.
• Fluorine Chemistry & Catalysis: Employed in methodological studies and as a ligand precursor in transition metal catalysis to explore new fluorination and C–H activation reactions.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom synthesis manufacturers for client-directed projects requiring bespoke fluorinated intermediates.

Basic Information

Product Name	(2,2-Difluorocyclobutyl)Methanol
CAS No.	1419101-11-3
Molecular Formula	C5H8F2O
Molecular Weight	122.11 g/mol
Synonyms	(2,2-Difluorocyclobutyl)methanol; 2,2-Difluorocyclobutanemethanol; (2,2-Difluorocyclobutane)methanol; Cyclobutanemethanol, 2,2-difluoro-; 1419101-11-3; 2,2-Difluorocyclobutylmethyl alcohol; (2,2-Difluorocyclobut-1-yl)methanol (alternative numbering)
EINECS	Contact for details

Quality Control

Every batch of (2,2-Difluorocyclobutyl)Methanol is produced and analyzed under strict quality management protocols to ensure consistency and purity for sensitive synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity, identity, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0% (Typical: 97-99%)
Water Content (KF)	≤ 0.5%
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.