Description

Bimekizumab CAS NO 1418205-77-2 is a high-purity, humanized monoclonal antibody designed as a dual inhibitor of interleukin-17A (IL-17A) and interleukin-17F (IL-17F). This targeted biologic is of significant value for its potent mechanism of action in modulating specific inflammatory pathways. It is primarily required by pharmaceutical research organizations, biotechnology companies, and contract development and manufacturing organizations (CDMOs) engaged in the development of advanced therapeutics for immune-mediated diseases.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of biologic drug products targeting psoriasis, psoriatic arthritis, and axial spondyloarthritis.
• Reference Standard in analytical laboratories for quality control, method development, and validation of biosimilar or generic versions.
• Research Grade Material for preclinical and clinical studies investigating the efficacy and safety of IL-17 pathway inhibition.
• Process Development in biomanufacturing for scale-up, purification process optimization, and characterization studies.
• Stability Studies to determine shelf-life, optimal storage conditions, and degradation profiles of the biologic.

Basic Information

Product Name	Bimekizumab
CAS No.	1418205-77-2
Molecular Formula	C6472H10012N1732O2016S46
Molecular Weight	Approx. 145 kDa
Synonyms	UCB 4940; BIMZ 92; BIMZ92; Anti-IL17A/F Antibody; IL-17A and IL-17F Dual Inhibitor; Monoclonal Antibody Bimekizumab; Bimzelx (Trade Name)
EINECS	Contact for details

Quality Control

Our Bimekizumab is manufactured under strict quality systems. Each batch is subjected to a comprehensive battery of analytical tests to ensure identity, purity, potency, and safety, meeting the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) detailing specifications such as purity by SEC-HPLC, biological activity, endotoxin levels, and host cell protein content are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (Mass Spec)	Conforms
Purity (SEC-HPLC)	≥ 98.0% (Monomer)
Protein Content (UV A280)	95.0 - 105.0 % of label claim
Biological Activity (Cell-Based Assay)	Conforms
Endotoxin	< 1.0 EU/mg
Host Cell Protein (HCP)	< 100 ppm
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.