Description

Biotin-Peg11-Amine CAS NO 1418022-42-0 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a biotin group for strong streptavidin/avidin binding and a terminal primary amine for conjugation to carboxylates or other reactive groups. This compound is essential for creating stable, site-specific bioconjugates with extended solubility and reduced immunogenicity due to its long, hydrophilic PEG spacer. It is primarily utilized by researchers and developers in pharmaceutical R&D, diagnostic assay development, and advanced drug delivery systems for labeling, purification, and targeted therapeutic applications.

Application

• ADC (Antibody-Drug Conjugate) Linker: Serves as a crucial component for constructing stable, cleavable, or non-cleavable linkers between monoclonal antibodies and cytotoxic payloads.
• Diagnostic Probe Conjugation: Used to biotinylate proteins, peptides, or oligonucleotides for use in ELISA, Western blot, and other immunoassay detection systems.
• Affinity Chromatography Ligand: Immobilized onto solid supports to create streptavidin-mimetic resins for the purification of tagged biomolecules.
• Surface Functionalization: Facilitates the modification of nanoparticles, quantum dots, or biosensor surfaces with biotin for specific capture and detection.
• Drug Delivery Platform: Incorporated into liposomes, dendrimers, or polymeric micelles to enable targeted delivery via biotin-receptor interactions.
• Protein and Peptide Modification: Enables the site-specific PEGylation (PEG11) of therapeutic proteins to enhance pharmacokinetic properties.
• Chemical Biology Tool: Employed in pull-down assays, protein interaction studies, and cellular imaging applications.

Basic Information

Product Name	Biotin-Peg11-Amine
CAS No.	1418022-42-0
Molecular Formula	C49H93N5O15S
Molecular Weight	1032.34 g/mol
Synonyms	Biotin-PEG11-NH2; Biotin-PEG11-Amine; 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2,5,8,11,14,17,20,23,26,29,32-undecaoxapentatriacontan-35-yl)pentanamide; Biotinylated PEG11 Amine; Biotin-PEG11-NH2 Linker; Amino-PEG11-Biotin; PEG11-Biotin-NH2; Biotin-Polyethylene Glycol11-Amine
EINECS	Contact for details

Quality Control

Our Biotin-Peg11-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure compliance with research and development standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	1032.34 ± 2 Da

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.