Description

7-Hydroxy Propranolol Glucuronide is a key metabolite of the widely used β-blocker, propranolol. This compound is of significant importance in pharmaceutical research and development, particularly for drug metabolism and pharmacokinetic (DMPK) studies. It serves as a critical reference standard for analytical laboratories in pharmaceutical, clinical research, and forensic toxicology sectors, enabling accurate quantification and metabolic profiling.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of propranolol metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for in vitro and in vivo studies to understand the metabolic pathways, bioavailability, and clearance of propranolol.
• Bioanalytical Method Development: Used to develop and validate sensitive LC-MS/MS, HPLC, and other chromatographic assays for clinical and preclinical trials.
• Forensic Toxicology: Aids in the precise identification and confirmation of propranolol ingestion in forensic investigations.
• Clinical Research: Supports studies investigating inter-individual variability in drug metabolism and personalized medicine approaches.
• Quality Control in Manufacturing: Employed in the QC labs of pharmaceutical manufacturers to ensure the consistency and purity of propranolol-based drug products.

Basic Information

Product Name	7-Hydroxy Propranolol Glucuronide
CAS No.	1418018-59-3
Molecular Formula	C22H33NO9
Molecular Weight	455.50 g/mol
Synonyms	1-(Isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol 7-Glucuronide; Propranolol 7-O-β-D-Glucuronide; 7-Hydroxypropranolol Glucuronide; 7-OH-Propranolol Glucuronide; 7-HPG; (2S)-1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol 7-β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our 7-Hydroxy Propranolol Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research and reference applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.