Description

1-Bromo-2,3-Difluoro-4-(Trifluoromethoxy)Benzene is a high-value, multi-functional fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring bromine, fluorine, and a trifluoromethoxy group, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients, as well as in materials science for creating specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorine-based drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core building block for fluorine-containing liquid crystals and organic light-emitting diode (OLED) materials, improving electronic properties and device performance.
• Polymer Science: Incorporated as a monomer or modifier in the synthesis of high-performance, specialty fluoropolymers with enhanced chemical resistance, thermal stability, and low surface energy.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to create complex biaryl structures.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel fluorinated compounds for various applications.

Basic Information

Product Name	1-Bromo-2,3-Difluoro-4-(Trifluoromethoxy)Benzene
CAS No.	1417569-62-0
Molecular Formula	C7H2BrF5O
Molecular Weight	276.99 g/mol
Synonyms	4-Bromo-2,3-difluoro-1-(trifluoromethoxy)benzene; 2,3-Difluoro-4-(trifluoromethoxy)bromobenzene; 1-Bromo-2,3-difluoro-4-(trifluoromethoxy)benzene; Benzene, 1-bromo-2,3-difluoro-4-(trifluoromethoxy)-; 2,3-Difluoro-4-trifluoromethoxybromobenzene; 4-(Trifluoromethoxy)-2,3-difluorobromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,3-Difluoro-4-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture. Store away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.