Description

1-(Difluoromethoxy)-2-Fluoro-3-(Trifluoromethyl)Benzene is a high-value, multi-fluorinated aromatic building block essential for advanced chemical synthesis. This compound matters for its unique trifluoromethyl and difluoromethoxy substituents, which are critical for modulating the lipophilicity, metabolic stability, and bioavailability of target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, as well as by material scientists exploring specialty polymers and liquid crystals. The CAS number for this compound is provided in the table below.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral therapeutic areas.
• Agrochemical Active Ingredient Synthesis: Used to construct advanced herbicides, fungicides, and insecticides where fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a fluorinated core structure in the synthesis of high-performance electronic display and lighting materials.
• Specialty Polymer Monomer: Incorporated into polymers to impart unique chemical resistance, thermal stability, and low surface energy properties.
• Fluorinated Ligand Synthesis: Used in organometallic chemistry to create sophisticated ligands for catalysis.
• Positron Emission Tomography (PET) Tracer Development: Acts as a precursor for introducing fluorine-18 radiolabels into diagnostic molecules.

Basic Information

Product Name	1-(Difluoromethoxy)-2-Fluoro-3-(Trifluoromethyl)Benzene
CAS No.	1417569-57-3
Molecular Formula	C9H4F6O
Molecular Weight	242.12 g/mol
Synonyms	2-Fluoro-α,α-difluoro-3-(trifluoromethyl)anisole; 2-Fluoro-3-(trifluoromethyl)phenyl difluoromethyl ether; 1-Difluoromethoxy-2-fluoro-3-trifluoromethylbenzene; Benzene, 1-(difluoromethoxy)-2-fluoro-3-(trifluoromethyl)-; 2-Fluoro-α,α-difluoro-3-(trifluoromethyl)anisole; DFMFB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethoxy)-2-Fluoro-3-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.