Description

5-Bromo-1,3-Dichloro-2-(Trifluoromethoxy)Benzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and trifluoromethoxy substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the halogen and trifluoromethoxy groups contribute to biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form biaryl structures.
• Fluorine Chemistry: The trifluoromethoxy group provides a source of fluorine atoms and is valuable for studying structure-activity relationships (SAR) in fluorinated compounds.
• Chemical Research & Development: Employed in academic and industrial labs as a standard or custom reagent for methodological studies and exploring new synthetic pathways.

Basic Information

Product Name	5-Bromo-1,3-Dichloro-2-(Trifluoromethoxy)Benzene
CAS No.	1417569-51-7
Molecular Formula	C7H2BrCl2F3O
Molecular Weight	309.90 g/mol
Synonyms	1-Bromo-3,5-dichloro-2-(trifluoromethoxy)benzene; 2-Bromo-4,6-dichloro-1-(trifluoromethoxy)benzene; Benzene, 5-bromo-1,3-dichloro-2-(trifluoromethoxy)-; 3,5-Dichloro-2-(trifluoromethoxy)bromobenzene; 5-Bromo-1,3-dichloro-2-(trifluoromethoxy)benzene; 1417569-51-7
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-1,3-Dichloro-2-(Trifluoromethoxy)Benzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity and purity against established specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.