Description

1-Bromo-5-Chloro-2-(Difluoromethoxy)-3-Fluoro-Benzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into their target structures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy and halogen groups contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a sophisticated monomer for creating advanced electronic materials used in displays and organic light-emitting diodes.
• Fluorinated Polymer Chemistry: Employed as a specialty monomer to introduce fluorine atoms into polymer backbones, enhancing material properties like chemical resistance and thermal stability.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for selective palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form complex biaryl systems.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on fluorination chemistry and the exploration of new chemical space.

Basic Information

Product Name	1-Bromo-5-Chloro-2-(Difluoromethoxy)-3-Fluoro-Benzene
CAS No.	1417567-82-8
Molecular Formula	C7H3BrClF3O
Molecular Weight	275.45 g/mol
Synonyms	3-Fluoro-2-(difluoromethoxy)-1-bromo-5-chlorobenzene; 1-Bromo-5-chloro-3-fluoro-2-(difluoromethoxy)benzene; 2-Bromo-6-chloro-3-(difluoromethoxy)-4-fluorobenzene; Benzene, 1-bromo-5-chloro-2-(difluoromethoxy)-3-fluoro-; 1417567-82-8
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-5-Chloro-2-(Difluoromethoxy)-3-Fluoro-Benzene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for advanced synthetic applications. Our quality commitment includes comprehensive identity confirmation, purity assay, and impurity profiling via modern chromatographic and spectroscopic techniques. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.