Description

1-Bromo-3-(Difluoromethoxy)-5-(Trifluoromethyl)Benzene is a high-value, multi-fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring bromine and fluorine substituents, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of specialty chemicals for electronic displays and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving their chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Material Science Research: Utilized in academic and industrial R&D for developing new fluorinated materials with specialized applications.

Basic Information

Product Name	1-Bromo-3-(Difluoromethoxy)-5-(Trifluoromethyl)Benzene
CAS No.	1417567-27-1
Molecular Formula	C8H4BrF5O
Molecular Weight	291.02 g/mol
Synonyms	3-Bromo-5-(trifluoromethyl)phenyl difluoromethyl ether; 1-Bromo-3-(difluoromethoxy)-5-(trifluoromethyl)benzene; Benzene, 1-bromo-3-(difluoromethoxy)-5-(trifluoromethyl)-; 3-(Difluoromethoxy)-5-(trifluoromethyl)bromobenzene; 5-Bromo-1-(difluoromethoxy)-3-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(Difluoromethoxy)-5-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.